Showing posts with label DNA. Show all posts
Showing posts with label DNA. Show all posts

Friday, July 03, 2015

Longer, Healthier Life

Human genome
Human genome (Photo credit: Wikipedia)
I think I would like to live past 100. What about you? I have seen pictures in newspapers of people who have done it without any Singularity type help. All of them were slim though.

If you do exercise, you can be as vibrant at 80 as you are at 40, almost.

How Computers Will Crack the Genetic Code and Improve Billions of Lives
Machine learning and data science will do more to improve healthcare than all the biological sciences combined. ..... the most epic challenge — extending the healthy human lifespan ..... Your genome consists of approximately 3.2 billion base pairs (your DNA) that literally code for "you." ..... Your genes code for what diseases you might get, whether you are good at math or music, how good your memory is, what you look like, what you sound like, how you feel, how long you'll likely live, and more. ..... Each person's genome produces a text file that is about 300 gigabytes. ...... The genome of the 100 trillion + microorganisms living in our bodies. There are 10 times as many microbial cells than human cells, and their effects on our bodies are enormous and massively understudied........ With millions and millions of documents/websites/publications online that were already translated, and a crowd of 500 million users to correct and "teach" the algorithm, GT can quickly and accurately translate between 90 different languages.

Tuesday, November 11, 2014

Innovating The Smartphone Battery

If my smartphone battery gave me four times more juice, it might last a full day of rigorous use. But it doesn't.

Battery is hard to do, but worth trying. But maybe Samsung should plot to move to one of the next big things: rHealth.

In fast food it is not McDonald's that is number one. The Chinese restaurants collectively are bigger. The same seems to be true of smartphones. Samsung is like McDonald's. It is number two.

Samsung’s Future Is Bleak Because Phones Themselves No Longer Matter
With the possible exception of radically improved battery life, hardware differences become about subtle preferences, not clear-cut metrics of superiority.

rHEALTH And One Drop Of Blood

This is a health care assistant that Fidel Castro could only have dreamed of. Like the smartphone is the computer for the final six billion, this device is the doctor for the final three billion, or maybe six. And I am sure there will be improvements. It is awesome as is, and it will get better. Finally a health "app" that actually does something serious pretty fast.

Heck, this is not just something for the have nots. This will displace many mainstream devices currently in use. This has the ease of a good old thermometer.

This Device Diagnoses Hundreds of Diseases Using a Single Drop of Blood
a portable handheld device that can diagnose hundreds of diseases using a single drop of blood with what Chan claims is gold-standard accuracy. ..... First hatched by DMI in response to a NASA challenge to create a diagnostics device that could work even in space, rHEALTH was portable from the beginning. ..... One small drop of blood is dropped into a small receptacle, where nanostrips and reagents react to the blood’s contents. The whole cocktail then goes through a spiral micro-mixer and is streamed past lasers that use variations in light intensity and scattering to come up with a diagnosis, from flu to a more serious illness such as pneumonia—or even Ebola—within a few minutes. ..... There’s also a vitals patch that users can wear to get continuous health readings—EKG, heart rate, body temperature—delivered to their smartphone or the rHEALTH device itself via a Bluetooth link. An app called CHAS (Comprehensive Health Assessment Unit) can walk the user through the process of self-diagnosis. ....... getting all the diagnostics technologies packed together into one handheld device ..... patients will need to give 1,500 times less blood than they would for regular tests ..... the device has even been tested in simulated lunar and zero gravity. “It’s a symphony of innovations, but we’ve pushed all of them individually to create the device” ..... rHEALTH is reliable for cell counts, HIV detection, vitamin D levels, and various protein markers in the body. The next challenges .. are adding more tests, scaling up production, and going through the laborious process of getting the rHEALTH commercialized. ...... three different models: the rHEALTH One, which will be used for translational research; the rHEALTH X, meant to be used as a kind of power tool for clinicians; and the rHEALTH X1, which will be available for consumers. ...... The goal is to create a universal, Star Trek-inspired medical diagnostic tool that detects up to 16 separate health conditions

Thursday, July 26, 2012

Life Secrets: Beyond Reach?

A slight mutation in the matched nucleotides c...
A slight mutation in the matched nucleotides can lead to chromosomal aberrations and unintentional genetic rearrangement. (Photo credit: Wikipedia)
Biology's Master Programmers
Since the mid-1980s Church has played a pioneering role in the development of DNA sequencing, helping—among his other achievements—to organize the Human Genome Project. To reach his office at Harvard Medical School, one enters a laboratory humming with many of the more than 50 graduate students and postdoctoral fellows over whom Church rules as director of the school's Center for Computational Genetics. ..... synthetic biology, an ambitious and radical approach to genetic engineering that attempts to create novel biological entities—everything from enzymes to cells and microbes—by combining the expertise of biology and engineering .... modify microƶrganisms to create new fuels and medical treatments. .... "It will change everything. People are going to live healthier a lot longer because of synthetic biology. You can count on it." ..... The very idea of synthetic biology is to purposefully engineer the DNA of living things so that they can accomplish tasks they don't carry out in nature. ...... a rapid drop in the cost of decoding and synthesizing DNA, combined with a vast increase in computer power and an influx into biology labs of engineers and computer scientists, has led to a fundamental change in how thoroughly and swiftly an organism's genetics can be modified. ..... we will be able to replace diseased tissues and organs by reprogramming cells to make new ones, create novel microbes that efficiently secrete fuels and other chemicals, and fashion DNA switches that turn on the right genes inside a patient's cells to prevent arteries from getting clogged. ..... The cost of both decoding DNA and synthesizing new DNA strands, he has calculated, is falling about five times as fast as computing power is increasing under Moore's Law ...... Up to now, it's proved stubbornly difficult to turn synthetic biology into a practical technology that can create products like cheap biofuels. Scientists have found that the "code of life" is far more complex and difficult to crack than anyone might have imagined a decade ago. What's more, while rewriting the code is easier than ever, getting it right isn't. ...... The idea, Church explains, is to sort through the variations to find "an occasional hopeful monster, just as evolution has done for millions of years." ..... no matter how elegantly compact the DNA code is, the biology it gives rise to is consistently more complex than anyone anticipated .... synthetic biology is genetic engineering on steroids ..... an expanding list of DNA circuits, including biosensors, oscillators, bacterial calculators, and similar molecular gadgetry ........ the claims that some synthetic-­biology companies made now appear to have been overly optimistic ...... Codon, in Church's words, was established to be the Intel of the bioengineering industry ...... Warp Drive, which was launched in January, employs fewer than a dozen full-time staffers and occupies only about 1,000 square feet of office and lab space in Cambridge, Massachusetts. But the startup, which has raised $125 million in investments ...... nature is particularly adept at creating chemicals that act safely and precisely on a desired biological target ...... "Nature seemed to have already engineered in complexities that drug chemists don't understand." ..... nature is still the best programmer.
A lot of people can't wrap their head around the fact that even biological processes are subject to engineering. It is not that different from metal engineering, just at a different scale.

It is like this friend of mine at high school. He just never could wrap his head round the fact that the earth was round. He wrote the right answer for exams and stuff. But he said, you know what, I just don't buy it. The earth feels flat to me, he said.
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Wednesday, March 02, 2011

Twitter, Facebook, Tumblr, LinkedIn

Image representing Twitter as depicted in Crun...Image via CrunchBaseSocial media is going to be so fundamental to all aspects of my company's operations that I have decided to put that into the DNA, into the culture. When you apply for a job with me, you email me the web addresses of your presences on these four platforms - Twitter, Facebook, Tumblr, LinkedIn - and a few paragraphs of who you are and why you are the best person for the job. That is where the conversation starts.

Obviously everyone on my corporate team is going to stay active on those four platforms. Obviously you are going to end up with some level of transparency, you are going to end up with what might look like a jellyfish organization. Overall I think that is a good thing.

Thursday, February 10, 2011

50 Hours Into One Five Minute Pitch

I might have a major pitch/presentation to make some time next week. And I think I will be putting about 50 hours of work into it. A lot of it will be bifurcated blogging. When I talk about the state of the global microfinance industry, that is a public blog post. But then the DNA formation that is taking place for my startup, that is stuff for my private blog.

There is also the no small matter of having a slide deck. I am not a huge fan of PowerPoint presentations. You can pack more into one blog post than you can into 50 slides. But slides have their place. And people still ask for them. So what I have come up with is a hybrid model. You get a slide deck, some words and phrases there link to some of my blog posts.